Alzheimerâ??s disease (AD) is a multifactorial neurodegenerative disorder that involves\ndifferent pathogenic mechanisms. In this regard, the goal of this study was the design and synthesis\nof new compounds with multifunctional pharmacological activity by molecular hybridization of\nstructural fragments of curcumin and resveratrol connected by anN-acyl-hydrazone function linked to\na 1,4-disubstituted triazole system. Among these hybrid compounds, derivative 3e showed the ability\nto inhibit acetylcholinesterase activity, the intracellular formation of reactive oxygen species as well\nas the neurotoxicity elicited by AB42 oligomers in neuronal SH-SY5Y cells. In parallel, compound 3e\nshowed a good profile of safety and ADME parameters. Taken together, these results suggest that 3e\ncould be considered a lead compound for the further development of AD therapeutics.
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